Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.

@article{Mullings2001SignalTA,
  title={Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.},
  author={Rebecca E. Mullings and Susan J. Wilson and Sarah M. Puddicombe and James L. Lordan and Fabio Bucchieri and Ratko Djukanovi{\'c} and Peter Howarth and Sarah Harper and Stephen T. Holgate and Donna E Davies},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 5},
  pages={832-8}
}
BACKGROUND Asthma is associated with increased production of IL-4 and IL-13. OBJECTIVE Because many of the effects of these cytokines are mediated by activation of signal transducer and activator of transcription 6 (STAT-6), we investigated expression and function of this transcription factor in the airways. METHODS STAT-6 expression was investigated through use of immunohistochemistry or RT-PCR applied to bronchial biopsy specimens or brushings from normal control or asthmatic subjects… CONTINUE READING