Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

@article{Humphreys1999SignalTA,
  title={Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.},
  author={Robin C. Humphreys and Lothar Hennighausen},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1999},
  volume={10 10},
  pages={685-94}
}
The mammary gland undergoes extensive tissue remodeling and cell death at the end of lactation in a process known as involution. We present evidence that the prolactin-activated transcription factor signal transducer and activator of transcription 5a (Stat5a) has a crucial role in the regulation of cell death during mammary gland involution. In a transforming growth factor-alpha transgenic mouse model that exhibited delayed mammary gland involution, the absence of Stat5a facilitated involution… CONTINUE READING

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