Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.

@article{OMalley2009SignalTA,
  title={Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.},
  author={John T O'Malley and Sarita Sehra and Vivian T Thieu and Qing Yu and Hua-Chen Chang and Gretta L. Stritesky and Evelyn T. Nguyen and Anubhav N. Mathur and David E. Levy and Mark H Kaplan},
  journal={Immunology},
  year={2009},
  volume={127 4},
  pages={
          587-95
        }
}
T-cell responses to a cytokine milieu instruct the development of multiple effector phenotypes. While transforming growth factor-beta(1) (TGF-beta(1)) inhibits the development of T helper type 1 (Th1) and Th2 cells, we demonstrate that like interleukin-6 (IL-6) and IL-4, IL-12 can inhibit the development of TGF-beta(1)-induced Foxp3-expressing adaptive T regulatory (aTreg) cells. Signal transducer and activator of transcription 4 (STAT4) is critical for the response to IL-12, although there is… CONTINUE READING

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