Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.

@article{Tsareva2007SignalTA,
  title={Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.},
  author={Svetlana A. Tsareva and Richard Moriggl and Florian Matthias Corvinus and Bernd Wiederanders and Alexander C. Sch{\"u}tz and Boris Kovacic and Karlheinz Friedrich},
  journal={Neoplasia},
  year={2007},
  volume={9 4},
  pages={
          279-91
        }
}
Signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in colorectal carcinomas (CRCs). Here, we define the relationship between STAT3 function and the malignant properties of colon carcinoma cells. Elevated activation of STAT3 enhances invasive growth of the CRC cell lines. To address mechanisms through which STAT3 influences invasiveness, the protease mRNA expression pattern of CRC biopsies was analyzed and correlated with the STAT3 activity status. These studies… CONTINUE READING

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