Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.

Abstract

The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families and plays a pivotal role in cardiac hypertrophy through gp130. To determine the physiological significance of STAT3 in vivo, transgenic mice with cardiac-specific overexpression of the Stat3 gene… (More)

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@article{Kunisada2000SignalTA, title={Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.}, author={Keita Kunisada and Seiji Negoro and Erin B. Tone and Masanobu Funamoto and Taku Osugi and S Yamada and Michio Okabe and T. Kishimoto and Keiko Yamauchi-Takihara}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2000}, volume={97 1}, pages={315-9} }