Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.

@article{Moreau2015SignalSR,
  title={Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.},
  author={H{\'e}l{\`e}ne D. Moreau and Fabrice Lema{\^i}tre and Kym R. Garrod and Zacarias Garcia and Ana-Maria Lennon-Dum{\'e}nil and Philippe Bousso},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 39},
  pages={
          12151-6
        }
}
T lymphocytes are highly motile cells that decelerate upon antigen recognition. These cells can either completely stop or maintain a low level of motility, forming contacts referred to as synapses or kinapses, respectively. Whether similar or distinct molecular mechanisms regulate T-cell deceleration during synapses or kinapses is unclear. Here, we used microfabricated channels and intravital imaging to observe and manipulate T-cell kinapses and synapses. We report that high-affinity antigen… CONTINUE READING
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