Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-κB control

@article{Marienfeld2001SignalspecificAP,
  title={Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-κB control},
  author={Ralf B. Marienfeld and Friederike Berberich-Siebelt and Ingolf Berberich and Andrea Denk and E. Serfling and Manfred Neumann},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={8142-8147}
}
RelB is an unusual member of the Rel/NF-κB family of transcription factors which are involved in oncogenic processes. Due to a relaxed control by the IκBs, the cytosolic NF-κB inhibitors, RelB is constitutively expressed in the nuclei of lymphoid cells. We show here that RelB is inducibly degraded upon activation of T cells in a fashion similar to the IκBs. However, RelB degradation differs from that of IκBs since it is not induced by TNFα but only by T cell receptor or TPA/ionomycin… CONTINUE READING
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