Signal sequences activate the catalytic switch of SRP RNA.

  title={Signal sequences activate the catalytic switch of SRP RNA.},
  author={Niels R Bradshaw and Saskia B Neher and David S. Booth and Peter J. Walter},
  volume={323 5910},
The signal recognition particle (SRP) recognizes polypeptide chains bearing a signal sequence as they emerge from the ribosome, and then binds its membrane-associated receptor (SR), thereby delivering the ribosome-nascent chain complex to the endoplasmic reticulum in eukaryotic cells and the plasma membrane in prokaryotic cells. SRP RNA catalytically accelerates the interaction of SRP and SR, which stimulates their guanosine triphosphatase (GTPase) activities, leading to dissociation of the… CONTINUE READING


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