Signal sequence recognition and protein targeting.

  title={Signal sequence recognition and protein targeting.},
  author={Robert Michael Stroud and Peter J. Walter},
  journal={Current opinion in structural biology},
  volume={9 6},
Intracellular traffic is often controlled not by highways, but by handshakes and partner introductions within a cellular network. Recently determined structures suggest how signal sequences are recognized and how the GTP affinities of the signal recognition particle and its receptor are coupled to the targeting of ribosomes to translocational membrane pores. The structure of signal peptidase suggests how it releases functional proteins.