Signal-regulatory protein is selectively expressed by myeloid and neuronal cells.

  title={Signal-regulatory protein is selectively expressed by myeloid and neuronal cells.},
  author={Sharon Adams and Luc J W van der Laan and Elizabeth Vernon-Wilson and Chantal Renardel de Lavalette and Ed A. D{\"o}pp and Christine D. Dijkstra and David Ll. Simmons and Timo K van den Berg},
  journal={Journal of immunology},
  volume={161 4},
Signal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC, and a cytoplasmic domain with two immunoreceptor with tyrosine-based inhibition motifs that can interact with src homology 2 domain-containing phosphatases. SIRP have previously been shown to inhibit signaling through receptor tyrosine kinases, but their physiologic function is unknown. Here we demonstrate by expression cloning that the… CONTINUE READING
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