Signal recognition particle: an essential protein-targeting machine.

  title={Signal recognition particle: an essential protein-targeting machine.},
  author={David Akopian and Kuang Shen and Xin Zhang and Shu-Ou Shan},
  journal={Annual review of biochemistry},
The signal recognition particle (SRP) and its receptor compose a universally conserved and essential cellular machinery that couples the synthesis of nascent proteins to their proper membrane localization. The past decade has witnessed an explosion in in-depth mechanistic investigations of this targeting machine at increasingly higher resolutions. In this review, we summarize recent work that elucidates how the SRP and SRP receptor interact with the cargo protein and the target membrane… CONTINUE READING