Signal perception and transduction: the role of protein kinases.

  title={Signal perception and transduction: the role of protein kinases.},
  author={Paul W. Schenk and B. Ewa Snaar-Jagalska},
  journal={Biochimica et biophysica acta},
  volume={1449 1},
Cells can react to environmental changes by transduction of extracellular signals, to produce intracellular responses. Membrane-impermeable signal molecules are recognized by receptors, which are localized on the plasma membrane of the cell. Binding of a ligand can result in the stimulation of an intrinsic enzymatic activity of its receptor or the modulation of a transducing protein. The modulation of one or more intracellular transducing proteins can finally lead to the activation or… CONTINUE READING