Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells.

Abstract

The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalyzed by Signal-peptide-peptidase-like 2a (SPPL2a) and that this… (More)
DOI: 10.1016/j.bbrc.2014.07.051

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