Signal-mediated sorting of neuropeptides and prohormones: secretory granule biogenesis revisited.

  title={Signal-mediated sorting of neuropeptides and prohormones: secretory granule biogenesis revisited.},
  author={Michael M. Glombik and H H Gerdes},
  volume={82 4},
Neuropeptides and hormones, in contrast to constitutive secretory proteins, are sorted to and stored in secretory granules and released upon a stimulus. During the last two decades, signals and mechanisms involved in their sorting to the regulated pathway of protein secretion have been addressed in numerous studies. Taken together these studies revealed three important features of regulated secretory proteins: aggregation, sorting signal motifs and membrane binding. Here we try to dissect the… CONTINUE READING

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