Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.

Abstract

A large group of E3 ubiquitin ligases is formed by the multisubunit SCF complex, whose core complex (Rbx1/Cul1-Cdc53/Skp1) binds one of many substrate recruiting F-box proteins to form an array of SCF ligases with diverse substrate specificities. It has long been thought that ubiquitylation by SCF ligases is regulated at the level of substrate binding. Here… (More)
DOI: 10.1016/j.molcel.2012.08.015

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@article{Yen2012SignalinducedDO, title={Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.}, author={James Yen and Karin M Flick and Christie V Papagiannis and Radhika Mathur and A W Tyrrell and Ikram Ouni and Robyn M. Kaake and Lan Huang and Peter Kaiser}, journal={Molecular cell}, year={2012}, volume={48 2}, pages={288-97} }