Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation

@inproceedings{Ai2011SignalinducedBR,
  title={Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation},
  author={Nanping Ai and Xiangming Hu and Feng Ding and Bingfei Yu and Huiping Wang and Xiaodong Lu and Kai Zhang and Yannan Li and Aidong Han and Wen Lin and Runzhong Liu and Ruichuan Chen},
  booktitle={Nucleic acids research},
  year={2011}
}
Bromodomain-containing protein Brd4 is shown to persistently associate with chromosomes during mitosis for transmitting epigenetic memory across cell divisions. During interphase, Brd4 also plays a key role in regulating the transcription of signal-inducible genes by recruiting positive transcription elongation factor b (P-TEFb) to promoters. How the… CONTINUE READING