Signal duration and the time scale dependence of signal integration in biochemical pathways

@article{Locasale2008SignalDA,
  title={Signal duration and the time scale dependence of signal integration in biochemical pathways},
  author={Jason W. Locasale},
  journal={BMC Systems Biology},
  year={2008},
  volume={2},
  pages={108 - 108}
}
Signal duration (e.g. the time over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proliferation, and developmental lineage commitments. Accompanying differences in signal duration are numerous downstream biological processes that require multiple steps of biochemical regulation. Here we present an analysis that investigates how simple biochemical motifs that involve multiple stages of regulation can be… CONTINUE READING
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