Signal detection and target gene induction by the CpxRA two-component system.

  title={Signal detection and target gene induction by the CpxRA two-component system.},
  author={Patricia A DiGiuseppe and Thomas J Silhavy},
  journal={Journal of bacteriology},
  volume={185 8},
The Cpx pathway is a two-component signal transduction system that senses a variety of envelope stresses, including misfolded proteins, and responds by upregulating periplasmic folding and trafficking factors. CpxA resides in the inner membrane and has both kinase and phosphatase activities. CpxR, the response regulator, mediates a response by activating transcription of stress-combative genes. Signal transduction is subject to feedback inhibition via regulon member CpxP and autoamplification… CONTINUE READING
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