Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.

@article{Weyrich1998SignaldependentTO,
  title={Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.},
  author={A. Weyrich and D. Dixon and R. Pabla and M. Elstad and T. McIntyre and S. Prescott and G. Zimmerman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 10},
  pages={
          5556-61
        }
}
  • A. Weyrich, D. Dixon, +4 authors G. Zimmerman
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Circulating human platelets lack nuclei, cannot synthesize mRNA, and are considered incapable of regulated protein synthesis. We found that thrombin-activated, but not resting, platelets synthesize Bcl-3, a member of the IkappaB-alpha family of regulatory proteins. The time- and concentration-dependent generation of Bcl-3 in platelets signaled by thrombin was blocked by translational inhibitors, by rapamycin, and by inhibitors of phosphatidylinositol-3-kinase, indicating that it occurs via a… Expand
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TLDR
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