Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif.

@article{Farhan2008SignaldependentEO,
  title={Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif.},
  author={Hesso Farhan and Veronika Reiterer and A. Kriz and H P Hauri and Margit Pavelka and Harald H. Sitte and Michael Freissmuth},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 6},
  pages={753-61}
}
The C-terminus of GABA transporter 1 (GAT1, SLC6A1) is required for trafficking of the protein through the secretory pathway to reach its final destination, i.e. the rim of the synaptic specialization. We identified a motif of three hydrophobic residues (569VMI571) that was required for export of GAT1 from the ER-Golgi intermediate compartment (ERGIC). This conclusion was based on the following observations: (i) GAT1-SSS, the mutant in which 569VMI571 was replaced by serine residues, was… CONTINUE READING