Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.

@article{KronesHerzig2006SignaldependentCO,
  title={Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.},
  author={Anja Krones-Herzig and Andrea Mesaros and Dagmar Metzger and Anja Sloth Ziegler and Ulrike Lemke and Jens C. Br{\"u}ning and Stephan Herzig},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 6},
  pages={3025-9}
}
Together with impaired glucose uptake in skeletal muscle, elevated hepatic gluconeogenesis is largely responsible for the hyperglycemic phenotype in type II diabetic patients. Intracellular glucocorticoid and cyclic adenosine monophosphate (cAMP)/protein kinase A-dependent signaling pathways contribute to aberrant hepatic glucose production through the induction of gluconeogenic enzyme gene expression. Here we show that the coactivator-associated arginine methyltransferase 1 (CARM1) is required… CONTINUE READING
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