Signal-dependent DNA binding and functional domains of the quorum-sensing activator TraR as identified by repressor activity.

@article{Luo1999SignaldependentDB,
  title={Signal-dependent DNA binding and functional domains of the quorum-sensing activator TraR as identified by repressor activity.},
  author={Z Q Luo and Stephen K Farrand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 16},
  pages={9009-14}
}
TraR, a member of the LuxR family of quorum-sensing transcription factors, is responsible for the population density-dependent regulation of Ti plasmid conjugal transfer. The protein requires as coinducer an acyl-homoserine lactone signal molecule called AAI (Agrobacterium autoinducer) that is produced by the bacteria themselves. TraR only activates its target genes, making it difficult to determine whether interaction with AAI is required for binding DNA or for initiating transcription. To… CONTINUE READING
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