Signal decay through a reverse phosphorelay in the Arc two-component signal transduction system.

@article{Georgellis1998SignalDT,
  title={Signal decay through a reverse phosphorelay in the Arc two-component signal transduction system.},
  author={Dimitris Georgellis and Ohsuk Kwon and Peter De Wulf and E. C. Lin},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 49},
  pages={32864-9}
}
Escherichia coli senses and signals anoxic or low redox conditions in its growth environment by the Arc two-component system. Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --> Asp --> His --> Asp phosphorelay pathway. In this study we used various combinations of wild-type and mutant ArcB domains to analyze in vitro the pathway for signal decay… CONTINUE READING