Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

@article{Wu2008SignalCT,
  title={Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species},
  author={Wen-Sheng Wu and Jia-Ru Wu and Chi-Tan Hu},
  journal={Cancer and Metastasis Reviews},
  year={2008},
  volume={27},
  pages={303-314}
}
Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling involved in uncontrolled tumor cell migration rely on the cross talks between integrin, receptor tyrosine kinase (RTK) and protein kinase C (PKC). The molecular mechanisms for cross talking between these migration-related signal cascades leading to sustained cell migration are reviewed… CONTINUE READING

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