Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2.

@article{Mallory2011SignalAD,
  title={Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2.},
  author={Michael J. Mallory and Jason K. Jackson and Brittany M Weber and Anthony Wei-Shine Chi and Florian Heyd and Kristen W. Lynch},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 11},
  pages={2184-95}
}
The HMG-box transcription factor LEF1 controls many developmentally regulated genes, including genes that activate expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes. At least two distinct isoforms of LEF1 are expressed, resulting from variable inclusion of LEF1 exon 6; however, the expression pattern of these isoforms and mechanism of splicing regulation have not been explored. Here we demonstrate that inclusion of LEF1 exon 6 is increased during thymic… CONTINUE READING
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Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells

  • B Hartmann
  • Genome Biol. 10:R11
  • 2009
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