Signal Transduction by the Chemokine Receptor CXCR5: Structural Requirements for G Protein Activation Analyzed by Chimeric CXCR1/CXCR5 Molecules

@inproceedings{Mller2001SignalTB,
  title={Signal Transduction by the Chemokine Receptor CXCR5: Structural Requirements for G Protein Activation Analyzed by Chimeric CXCR1/CXCR5 Molecules},
  author={G. M{\"u}ller and M. Lipp},
  booktitle={Biological chemistry},
  year={2001}
}
Abstract The human chemokine receptors CXCR5 and CXCR1 activate signaling pathways via pertussis toxinsensitive as well as insensitive G proteins. CXCR5 induces Ca2+signaling and chemotaxis independently of inhibitory G proteins, whereas the same signaling pathways are entirely dependent on inhibitory G proteins for CXCR1. In contrast, activation of the MAP kinase cascade via ERK1/2 is a pertussis toxinsensitive signaling event for both receptors. Using chimeric CXCR1/CXCR5 receptors we… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Regulatory mechanisms that modulate signalling by G-protein-coupled receptors.
G protein-coupled signal transduction pathways for interleukin-8.
G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition
  • J. Wess
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1997
Human chemokines: an update.
Structure and functional expression of a human interleukin-8 receptor.
Identification of G‐protein binding sites of the human interleukin‐8 receptors by functional mapping of the intracellular loops
  • Bassam B. Damaj, S. McColl, +4 authors Paul H. Naccache
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
...
1
2
3
4
...