Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold

  title={Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold},
  author={A. Daskalov and B. Habenstein and D. Martinez and A. J. Debets and R. Sabat{\'e} and A. Loquet and S. Saupe},
  journal={PLoS Biology},
  • A. Daskalov, B. Habenstein, +4 authors S. Saupe
  • Published 2015
  • Biology, Medicine
  • PLoS Biology
  • In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the HET-S pore-forming protein. The HET-s β-solenoid prion fold serves as a template for converting the HET-S prion-forming domain into the same fold. This conversion, in turn, activates the HET-S pore-forming domain. The gene immediately adjacent to het-S encodes NWD2, a Nod-like receptor (NLR) with an N-terminal motif similar to the elementary repeat unit of the β-solenoid fold. NLRs are immune… CONTINUE READING
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