Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels


Pentameric ligand-gated ion channels are activated by the binding of agonists to a site distant from the ion conduction path. These membrane proteins consist of distinct ligand-binding and pore domains that interact via an extended interface. Here, we have investigated the role of residues at this interface for channel activation to define critical… (More)
DOI: 10.1371/journal.pbio.1002393


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