Signal Transduction and the Control of Gene Expression
@article{Brivanlou2002SignalTA, title={Signal Transduction and the Control of Gene Expression}, author={A. Brivanlou and J. Darnell}, journal={Science}, year={2002}, volume={295}, pages={813 - 818} }
More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.
Topics from this paper
654 Citations
Ordered recruitment: gene-specific mechanism of transcription activation.
- Biology, Medicine
- Molecular cell
- 2002
- 258
- PDF
Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later.
- Biology, Medicine
- Gene
- 2012
- 60
- PDF
Signal-induced functions of the transcription factor TFII-I.
- Biology, Medicine
- Biochimica et biophysica acta
- 2007
- 45
Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis
- Medicine, Biology
- Nucleic acids research
- 2011
- 7
- PDF
A comparative analysis of the 'other roles' of transcriptional factors from pathogenic organisms.
- Biology, Medicine
- Gene
- 2016
- 1
Latency of transcription factor Stp1 depends on a modular regulatory motif that functions as cytoplasmic retention determinant and nuclear degron
- Biology, Medicine
- Molecular biology of the cell
- 2014
- 17
References
SHOWING 1-10 OF 147 REFERENCES
Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells.
- Biology, Medicine
- Trends in biochemical sciences
- 2000
- 375
- PDF
Genetic regulatory mechanisms in the synthesis of proteins.
- Biology, Medicine
- Journal of molecular biology
- 1961
- 4,309
- PDF
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.
- Biology, Medicine
- Science
- 1986
- 991
Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination.
- Biology, Medicine
- Current opinion in cell biology
- 1995
- 159
Notch signal transduction: a real rip and more.
- Biology, Medicine
- Current opinion in genetics & development
- 2000
- 205
- PDF
Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.
- Biology, Medicine
- Trends in biochemical sciences
- 1998
- 523
Transcriptional control of Hox genes in the vertebrate nervous system.
- Biology, Medicine
- Current opinion in genetics & development
- 1996
- 44
The role of STATs in transcriptional control and their impact on cellular function
- Biology, Medicine
- Oncogene
- 2000
- 1,139
- PDF
Transcriptional repression: the long and the short of it.
- Biology, Medicine
- Genes & development
- 2001
- 296
- PDF