Signal Transduction The Lipid Kinase PI 4 KIII b Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab 11 a

@inproceedings{Morrow2014SignalTT,
  title={Signal Transduction The Lipid Kinase PI 4 KIII b Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab 11 a},
  author={Anne A. Morrow and Mohsen Amir Alipour and Dave Bridges and Zemin Yao and Alan R. Saltiel and Jonathan M. Lee},
  year={2014}
}
Emerging evidence now implicates phosphatidylinositol 4-kinases (PI4K), enzymes that generate PI(4)P from phosphatidylinositol (PtdIns), in cancer. In this study, we investigate the role of PI4KIIIb, one of four mammalian PI4Ks, in breast cancer. Although PI4KIIIb protein levels are low in normal breast tissue, we find that approximately 20% of primary… CONTINUE READING