Signal Transduction The Adherens Junction Protein Afadin Is an AKT Substrate that Regulates Breast Cancer Cell Migration

The PI3K–AKT signaling pathway regulates all phenotypes that contribute to progression of human cancers, including breast cancer. AKT mediates signal relay by phosphorylating numerous substrates, which are causally implicated in biologic responses such as cell growth, survival, metabolic reprogramming, migration, and invasion. Here a new AKT substrate is… CONTINUE READING