Signal Transduction—Associated and Cell Activation—Linked Antigens Expressed in Human Mast Cells

  title={Signal Transduction—Associated and Cell Activation—Linked Antigens Expressed in Human Mast Cells},
  author={P. Valent and M. Ghannadan and A. Hauswirth and G. Schernthaner and W. Sperr and M. Arock},
  journal={International Journal of Hematology},
  • P. Valent, M. Ghannadan, +3 authors M. Arock
  • Published 2002
  • Biology, Medicine
  • International Journal of Hematology
  • Mast cells (MCs) are multifunctional hematopoietic effector cells that produce and release an array of biologically active mediator substances. Growth and functions of MCs are regulated by cytokines, other extracellular factors, surface and cytoplasmic receptors, oncogene products, and a complex network of signal transduction cascades. Key regulators of differentiation of MCs appear to be stem cell factor (SCF) and its tyrosine kinase receptor KIT (c-kit proto-oncogene product=CD117… CONTINUE READING
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