Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

@article{Sotiropoulos1999SignalRegulatedAO,
  title={Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics},
  author={Athanassia Sotiropoulos and Dziugas Gineitis and John W. R. Copeland and Richard Treisman},
  journal={Cell},
  year={1999},
  volume={98},
  pages={159-169}
}

Figures from this paper

LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics
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A role for LIMK in SRF activation, and functional cooperation between RhoA-controlled LIMK and mDia effector pathways are demonstrated.
Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene*
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Results show that at least two classes of SRF target genes can be distinguished on the basis of their relative sensitivity to RhoA-actin and MEK-ERK signaling pathways.
STARS, a Striated Muscle Activator of Rho Signaling and Serum Response Factor-dependent Transcription*
TLDR
A novel, evolutionarily conserved actin-binding protein, called STARS (striated muscle activator of Rho signaling), is described that is expressed specifically in cardiac and skeletal muscle cells and provides a potential mechanism for specifically enhancing Rho-dependent transcription in Muscle cells and for linking changes in actin dynamics to gene transcription.
Muscle-Specific Signaling Mechanism That Links Actin Dynamics to Serum Response Factor
TLDR
The ability of STARS to promote the nuclear localization of MRTFs and SRF-mediated transcription provides a potential muscle-specific mechanism for linking changes in actin dynamics and sarcomere structure with striated muscle gene expression.
Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL
TLDR
A function of nuclear actin is reported in the regulation of MAL, a coactivator of the transcription factor serum response factor (SRF), and fluorescence resonance energy transfer analysis demonstrates that the MAL-actin interaction responds to extracellular signals.
Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor.
TLDR
Results provide strong evidence that G-actin, or a subpopulation of it, plays a direct role in signal transduction to SRF.
Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL
Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors
TLDR
Data suggest that inhibition of proteasome results in down- regulation of SMA expression via up-regulation of c-Jun and repression of SRF activity at the level of DNA binding.
Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression
TLDR
The possible mechanisms and key proteins that may mediate the transcriptional regulation by Rho GTPases through actin are discussed.
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Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements.
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