Signal Recognition Protein ( SRP ) Mediates the Selective Binding to Microsomal Membranes of In-Vitro-Assembled Polysomes Synthesizing Secretory Protein

Translocation-competent microsomal membrane vesicles of dog pancreas were shown to selectively bind nascent, in vitro assembled polysomes synthesizing secretory protein (bovine prolactin) but not those synthesizing cytoplasmic protein (alpha and beta chain of rabbit globin) . This selective polysome binding capacity was abolished when the microsomal… CONTINUE READING