Signal-Mediated, AP-1/Clathrin-Dependent Sorting of Transmembrane Receptors to the Somatodendritic Domain of Hippocampal Neurons

@article{Faras2012SignalMediatedAS,
  title={Signal-Mediated, AP-1/Clathrin-Dependent Sorting of Transmembrane Receptors to the Somatodendritic Domain of Hippocampal Neurons},
  author={Ginny G. Far{\'i}as and Loreto Cuitino and Xiaoli Guo and Xuefeng Ren and Michal Jarnik and Rafael Mattera and Juan S Bonifacino},
  journal={Neuron},
  year={2012},
  volume={75},
  pages={810-823}
}
Plasma membranes of the somatodendritic and axonal domains of neurons are known to have different protein compositions, but the molecular mechanisms that determine this polarized protein distribution remain poorly understood. Herein we show that somatodendritic sorting of various transmembrane receptors in rat hippocampal neurons is mediated by recognition of signals within the cytosolic domains of the proteins by the μ1A subunit of the adaptor protein-1 (AP-1) complex. This complex, in… CONTINUE READING
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