Sigma32-mediated negative regulation of Salmonella pathogenicity island 1 expression.

  title={Sigma32-mediated negative regulation of Salmonella pathogenicity island 1 expression.},
  author={Mari Matsui and Akiko Takaya and Tomoko Yamamoto},
  journal={Journal of bacteriology},
  volume={190 20},
Salmonella pathogenicity island 1 (SPI1) enables infecting salmonellae to invade the intestinal epithelium and induce a proinflammatory response and macrophage cell death. SPI1 expression is controlled by a complex cascade with several transcriptional regulators within the island and global regulators outside it. Previously, we reported that DnaK-depleted salmonellae could neither invade epithelial cells nor secrete SPI1-encoded proteins, suggesting that DnaK is involved in the expression of… CONTINUE READING
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