Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells

@article{Paul1993SigmaRM,
  title={Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells},
  author={Ian A. Paul and Anthony S. Basile and Eduardo Rojas and Moussa B. H. Youdim and B de Costa and Phil Skolnick and Harvey B Pollard and Gemma A. J. Kuijpers},
  journal={The FASEB Journal},
  year={1993},
  volume={7},
  pages={1171 - 1178}
}
Neither the physiological function of sigma (σ) receptors nor the cellular mechanism responsible for the pharmacological effects of σ receptor ligands is known. We now report that σ receptor ligands noncompetitively inhibit nicotine‐stimulated catecholamine release from bovine adrenal chromaffin cells in a concentration‐dependent and reversible manner. The rank order of potency of ligands to inhibit nicotine‐stimulated catecholamine release is significantly correlated (P < 0.005) with that… Expand
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TLDR
This review of the literature examines the mechanism of action of the σRs, their interaction with neurotransmitters, pharmacology, location and adverse effects mediated through them. Expand
sigma Receptor Activation Does Not Mediate Fentanyl-Induced Attenuation of Muscarinic Coronary Contraction
TLDR
Neither sigma nor opioid receptoractivation is a prerequisite for fentanyl-induced inhibition of muscarinic coronary contraction, and the effects of inhibiting various points in the signal transduction pathway distal to naloxone-sensitive opioid receptor activation on acetylcholine-induced contraction are assessed. Expand
Differential effects of cytochrome P-450 induction on ligand binding to σ receptors
The identity of the sigma receptor as a form of cytochrome P-450 was investigated in rats treated with 3-methylcholanthrene or phenobarbital. The density of [3H]N,N'-di(o-tolyl)guanidine (DTG)Expand
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