Sigma receptors are expressed in human non-small cell lung carcinoma.

  title={Sigma receptors are expressed in human non-small cell lung carcinoma.},
  author={Christy S. John and Wayne D. Bowen and V. M. S. Vishnu Varma and John G. McAfee and Terry W. Moody},
  journal={Life sciences},
  volume={56 26},
N-(2-piperidinoethyl)4-iodobenzamide), IPAB, was used to characterize sigma receptors in non-small cell lung cancer (NSCLC) cell lines. 125IPAB bound with high affinity to large cell carcinoma (NCI-H1299), adenocarcinoma (NCI-H838), and lung carcinoid (NCI-H727) cell lines. Specific IPAB binding was inhibited with high affinity by haloperidol (Ki = 0.6 nM), IPAB (Ki = 14 nM) and 1,3-ditolyl guanidine (DTG) (Ki = 40 nM). Relative to other receptor ligands, IPAB was not readily internalized at 37… CONTINUE READING


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