Sigma receptors and sigma ligands: background to a pharmacological enigma.

@article{Leonard2004SigmaRA,
  title={Sigma receptors and sigma ligands: background to a pharmacological enigma.},
  author={Brian E. Leonard},
  journal={Pharmacopsychiatry},
  year={2004},
  volume={37 Suppl 3},
  pages={S166-70}
}
Although it is now well established that the sigma receptors are distinct from neurotransmitter, neuropeptide and steroid receptors, their precise physiological role, and possible involvement in the pathology of neurological and psychiatric disorders, remains an enigma. The purpose of this short review is to provide a basis upon which to explain the pharmacological properties of such a diverse group of drugs as the antidepressants, antipsychotics and neuroprotective agents. However, a greater… CONTINUE READING
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