Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.

@article{Hudzik1993SigmaRE,
  title={Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.},
  author={Thomas J Hudzik and B de Costa and Donald E. McMillan},
  journal={European journal of pharmacology},
  year={1993},
  volume={236 2},
  pages={
          279-87
        }
}
In order to more fully characterize sigma ligand-induced emesis in the pigeon, the effects of a number of compounds were tested alone or in combination with ditolyguanidine (DTG). The drugs tested could be categorized into three types: agonists, which produced the emetic response (DTG > amitriptyline > BD 737 > thioridazine), antagonists, which effectively antagonized the effects of DTG (haloperidol > BMY 14802 > BD 1139 > chlorpromazine), and agents which did not produce the emetic response on… Expand
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