Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals.

@article{Hashimoto2006SigmaRL,
  title={Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals.},
  author={Kenji Hashimoto and Kiichi Ishiwata},
  journal={Current pharmaceutical design},
  year={2006},
  volume={12 30},
  pages={
          3857-76
        }
}
Sigma receptors are classified into sigma(1) and sigma(2) subtypes. These subtypes display a different tissue distribution and a distinct physiological and pharmacological profile in the central and peripheral nervous system. The characterization of these subtypes and the discovery of new specific sigma receptor ligands demonstrated that sigma receptors are novel targets for the therapeutic treatment of neuropsychiatric diseases (schizophrenia, depression, and cognition), brain ischemia, and… CONTINUE READING

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