Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.

@article{Ha2011SigmaR1,
  title={Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.},
  author={Yonju Ha and Ying Dun and Muthusamy Thangaraju and Jennifer N Duplantier and Zheng Dong and Kebin Liu and Vadivel Ganapathy and Sylvia B. Smith},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 1},
  pages={527-40}
}
PURPOSE To investigate the mechanism of σ receptor 1 (σR1) neuroprotection in retinal neurons. METHODS Oxidative stress, which is implicated in diabetic retinopathy, was induced in mouse primary ganglion cells (GCs) and RGC-5 cells, and the effect of the σR1 ligand (+)-pentazocine on pro- and anti-apoptotic and endoplasmic reticulum (ER) stress gene expression was examined. Binding of σR1 to BiP, an ER chaperone protein, and σR1 phosphorylation status were examined by immunoprecipitation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…