Sigma-i and Sigma-2 Receptors Are Expressed in a Wide Variety of Human and Rodent Tumor Cell Lines

@inproceedings{VilnerSigmaiAS,
  title={Sigma-i and Sigma-2 Receptors Are Expressed in a Wide Variety of Human and Rodent Tumor Cell Lines},
  author={Bertold J. Vilner and Christy and Susan D. John and Wayne D. Bowen}
}
Thirteen tumor-derived cell lines of human and nonhuman origin and from various tissues were examined for the presence and density of sigma-i and sigma-2 receptors. Sigma-i receptors of a crude membrane fraction were labeled using [3H](+)-pentazocine, and sigma-2 receptors were labeled with [3H11,3-di-o-tolylguanidine ([3HJDTG); in the presence or absence ofdextrallorphan. [3H](+)-Pentazocine-binding sites were het erogeneous. In rodent cell lines (e.g., C6 glioma, N1E-115 neuroblastoma, and… CONTINUE READING