Sigma factor B and RsbU are required for virulence in Staphylococcus aureus-induced arthritis and sepsis.

@article{Jonsson2004SigmaFB,
  title={Sigma factor B and RsbU are required for virulence in Staphylococcus aureus-induced arthritis and sepsis.},
  author={Ing-Marie Jonsson and Staffan Arvidson and Simon Foster and Andrzej Tarkowski},
  journal={Infection and immunity},
  year={2004},
  volume={72 10},
  pages={6106-11}
}
The prototype Staphylococcus aureus strain 8325-4 produces high levels of hemolysins and proteases. Recently it has been shown that this property depends on a deficiency of sigma factor B (SigB) activity controlling the activation of regulatory genes such as agr and sarA. SigB deficiency is in turn due to a mutation in the rsbU gene, which is required for posttranslational activation of SigB. The rsbU defect of strain 8325-4 has recently been repaired, and we used this strain (SH1000), along… CONTINUE READING

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