Sigma antagonists potentiate opioid analgesia in rats

@article{Chien1995SigmaAP,
  title={Sigma antagonists potentiate opioid analgesia in rats},
  author={C. Chien and G. Pasternak},
  journal={Neuroscience Letters},
  year={1995},
  volume={190},
  pages={137-139}
}
In mice, activation of sigma1 receptors antagonizes opioid analgesia. Sigma antagonists potentiate opioid analgesia, implying that the anti-opioid sigma system is tonically active. Co-administration of haloperidol with the mu opioid morphine, the kappa 1 analgesic U50,488H or the kappa 3 agonist naloxone benzoylhydrazone enhances the analgesic activity of all agents. The effect results from sigma receptor blockade since (-)sulpiride, a selective D2 antagonist which does not block sigma… Expand
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