Sigma Receptor Binding Assays.

  title={Sigma Receptor Binding Assays.},
  author={Uyen B. Chu and Arnold E. Ruoho},
  journal={Current protocols in pharmacology},
Sigma receptors, both Sigma-1(S1R) and Sigma-2 (S2R), are small molecule-regulated, primarily endoplasmic reticulum (ER) membrane-associated sites. A number of drugs bind to sigma receptors, including the antipsychotic haloperidol and (+)-pentazocine, an opioid analgesic. Sigma receptors are implicated in many central nervous system disorders, in particular Alzheimer's disease and conditions associated with motor control, such as Amyotrophic Lateral Sclerosis (ALS). Described in this unit are… CONTINUE READING