Sigma Receptor 1 Is Preferentially Involved in Modulation of N-Methyl-D-Aspartate Receptor-Mediated Light-Evoked Excitatory Postsynaptic Currents in Rat Retinal Ganglion Cells

@inproceedings{Zhong2011SigmaR1,
  title={Sigma Receptor 1 Is Preferentially Involved in Modulation of N-Methyl-D-Aspartate Receptor-Mediated Light-Evoked Excitatory Postsynaptic Currents in Rat Retinal Ganglion Cells},
  author={Y Zhong},
  year={2011}
}
Using patch-clamp whole-cell recording, we investigated how activation of the sigma receptor 1 ( R1) modulates light-evoked excitatory postsynaptic currents (eEPSCs) of ganglion cells (GCs) in rat retinal slice preparations. Bath application of the R1 agonist SKF10047 (SKF) suppressed NmethylD -aspartate (NMDA) receptor-mediated eEPSCs at different holding potentials in ON, OFF and ON-OFF GCs, and the effects were blocked when the preparations were preincubated with the R1 antagonist BD1047. In… CONTINUE READING

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