Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines.

@article{Crawford2002Sigma2RA,
  title={Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines.},
  author={Keith W Crawford and Wayne D. Bowen},
  journal={Cancer research},
  year={2002},
  volume={62 1},
  pages={313-22}
}
We have reported previously that sigma-2 receptors are expressed in high densities in a variety of tumor cell types (B. J. Vilner et al., Cancer Res., 55: 408-413, 1995) and that various sigma ligands have cytotoxic effects (B. J. Vilner et al., J. Neurosci., 15: 117-134, 1995). Other investigators have demonstrated increased expression of sigma-2 receptors in rapidly proliferating tumors (R. H. Mach et al., Cancer Res., 57: 156-161, 1997) and the ability of some sigma ligands to inhibit… CONTINUE READING

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We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis .
We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis .
We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis .
We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis .
We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis .
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