Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.

@article{Sahn2017Sigma2R,
  title={Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.},
  author={James J. Sahn and G. Mejia and P. Ray and Stephen F Martin and T. Price},
  journal={ACS chemical neuroscience},
  year={2017},
  volume={8 8},
  pages={
          1801-1811
        }
}
Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be a potential target for neuropathic pain therapeutics, and antagonists for this receptor are effective in preclinical models and are currently in phase II clinical trials. Conversely, relatively little is known about σ2R, which has recently been identified as transmembrane protein 97 (Tmem97). We generated a series of σ1R and σ2R/Tmem97 agonists and antagonists and tested… Expand
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