Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

@article{Mancuso2012Sigma1RAI,
  title={Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice},
  author={Renzo Mancuso and S. C. Olivan and Amaya Rando and Caty Casas and Rosario Osta and Xavier Garc{\'i}a Navarro},
  journal={Neurotherapeutics},
  year={2012},
  volume={9},
  pages={814-826}
}
Amyotrophic lateral sclerosis is a neurodegenerative disorder characterized by progressive weakness, muscle atrophy, and paralysis due to the loss of upper and lower motoneurons (MNs). Sigma-1 receptor (sigma-1R) activation promotes neuroprotection after ischemic and traumatic injuries to the central nervous system. We recently reported that sigma-1R agonist (PRE-084) improves the survival of MNs after root avulsion injury in rats. Moreover, a mutation of the sigma-1R leading to frontotemporal… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 55 CITATIONS, ESTIMATED 57% COVERAGE

Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury

  • Cellular and Molecular Neurobiology
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.

  • Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2012

Activation of the ζ receptor 1 suppresses NMDA responses in rat retinal ganglion cells

Zhang X-J, Liu L-L, Jiang S-X, Zhong Y-M, Yang X-L
  • Neuroscience
  • 2011
VIEW 2 EXCERPTS